Sodium trifluoroacetate
USP/1615138 - United States Pharmacopeia (USP) Reference Standard
Synonym: Sodium trifluoroacetate; Trifluoroacetic acid sodium salt
CAS Number: 2923-18-4
Empirical Formula (Hill Notation): C2F3NaO2
Molecular Weight: 136.01
MDL Number: MFCD00013217
Linear Formula: CF3COONa
Product Type: Chemical
| API family | sodium trifluoroacetate |
| application(s) | USP Biologics pharmaceutical (small molecule) |
| density | 1.49 g/mL (lit.) |
| form | powder |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C2HF3O2.Na/c3-2(4,5)1( |
| InChI key | UYCAUPASBSROMS-UHFFFAOYSA |
| manufacturer/tradename | USP |
| mp | 205-207 °C (dec.) (lit.) |
| SMILES string | [Na+].[O-]C(=O)C(F)(F)F |
| Application: | Sodium trifluoroacetate reference standard intended for use in specified quality tests and assays. Also used to prepare trifluoroacetic acid (TFA) Stock solution to determine the amount of trifluoroacetic acid (TFA) in peptides according to the given below general chapter of United States Pharmacopeia (USP): • ⟨503.1⟩ Trifluoroacetic acid (TFA) in peptides |
| General description: | Sodium trifluoroacetate (TFA) is a commonly encountered residual reagent or counter-ion in peptide synthesis and purification. It is often present due to the use of trifluoroacetic acid in cleavage and purification steps. The USP standard supports the identification and quantification of TFA in peptide active pharmaceutical ingredients (APIs) and formulations. The USP biologics peptides category encompasses a diverse range of therapeutic peptides that are essential in managing various medical conditions. These peptides, typically consisting of amino acid sequences of 40 residues or less, are critical for the development of high-quality medicines. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of peptide therapeutics throughout their lifecycle. The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics. |
| Other Notes: | Sales restrictions may apply. |
| Other Notes: | This product is part of the USP Biologics program. |
| Hazard statements | H412 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 205-207 °C (dec.) (lit.) |
| Density | 1.49 g/mL (lit.) |
| UNSPSC | 41116107 |