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Proguanil hydrochloride

USP/1568040 - United States Pharmacopeia (USP) Reference Standard

Synonym: Chlorguanide; N1-(4-Chlorophenyl)-N5-isopropylbiguanide

CAS Number: 637-32-1
Empirical Formula (Hill Notation): C11H16ClN5·HCl
Molecular Weight: 290.19
MDL Number: MFCD01732193
Linear Formula: C11H16ClN5·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-1568040-200MG 200 mg
 $394.00
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API family proguanil
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
InChI key SARMGXPVOFNNNG-UHFFFAOYSA-N
manufacturer/tradename USP
SMILES string Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
Analysis Note: These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
Application: Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Biochem/physiol Actions: Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
Biochem/physiol Actions: Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P330 + P331 + P310
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 41116107

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