Methyl isobutyl ketone
USP/1430203 - United States Pharmacopeia (USP) Reference Standard
Synonym: 4-Methyl-2-pentanone; Isobutyl methyl ketone; Isopropylacetone; MIBK; Methyl isobutyl ketone
CAS Number: 108-10-1
Empirical Formula (Hill Notation): C6H12O
Molecular Weight: 100.16
MDL Number: MFCD00008938
Linear Formula: (CH3)2CHCH2COCH3
Product Type: Chemical
| application(s) | USP Biologics pharmaceutical (small molecule) |
| autoignition temp. | 840 °F |
| bp | 117-118 °C |
| density | 0.801 g/mL at 25 °C (lit.) |
| expl. lim. | 1.2-8 %, 93 °F |
| form | liquid |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C6H12O/c1-5(2)4-6(3)7/ |
| InChI key | NTIZESTWPVYFNL-UHFFFAOYSA |
| manufacturer/tradename | USP |
| mp | −80 °C (lit.) |
| refractive index | n |
| SMILES string | CC(C)CC(C)=O |
| vapor density | 3.5 (vs air) |
| Analysis Note: | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Application: | Methyl isobutyl ketone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. |
| General description: | Methyl isobutyl ketone is a versatile solvent used in various pharmaceutical and biologic formulations. It aids in the dissolution of lipophilic compounds and is employed during the extraction and purification processes. MIBK’s low volatility and solvent properties make it ideal for use in biologic formulations where stability and consistency are key. The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Other Notes: | This product is part of USP Biologics Program. |
| Other Notes: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha |
| Other Notes: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia . |
| Symbol |   GHS02,GHS07 |
| Signal word | Danger |
| Hazard statements | H225 - H319 - H332 - H335 |
| Precautionary statements | P210 - P233 - P240 - P241 - P304 + P340 + P312 - P305 + P351 + P338 |
| RIDADR | UN1245 - class 3 - PG 2 - Methyl isobutyl ketone |
| WGK Germany | WGK 1 |
| Flash Point(F) | 57.2 °F - closed cup |
| Flash Point(C) | 14 °C - closed cup |
| Supplemental Hazard Statements | EUH066 |
| bp | 117-118 °C |
| mp | −80 °C (lit.) |
| Density | 0.801 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 41116107 |