Synonym: Propyl gallate; 3,4,5-Trihydroxybenzoic acid propyl ester
CAS Number: 121-79-9
Empirical Formula (Hill Notation): C10H12O5
Molecular Weight: 212.20
MDL Number: MFCD00002196
Linear Formula: 3,4,5-(HO)3C6H2CO2CH2CH2CH3
Product Type: Chemical
InChI |
1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3 |
InChI key |
ZTHYODDOHIVTJV-UHFFFAOYSA-N |
manufacturer/tradename |
EDQM |
mp |
146-149 °C (lit.) |
SMILES string |
CCCOC(=O)c1cc(O)c(O)c(O)c1 |
storage temp. |
2-8°C |
Application: |
Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein. |
Biochem/physiol Actions: |
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. |
Biochem/physiol Actions: |
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis. |
General description: |
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia . |
Other Notes: |
Sales restrictions may apply. |
Packaging: |
Unit quantity: 80 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
Reconstitution: |
Prepare a 0.1M solution in glycerol:PBS (9:1) |
mp |
146-149 °C (lit.) |
Storage Temp. |
2-8°C |
UNSPSC |
41116107 |