Synonym: Folinic acid calcium salt hydrate; 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt; 5-HCO-H4PteGlu; Calcium folinate; Citrovorum factor calcium salt; Leucovorin calcium salt
CAS Number: 1492-18-8 (anhydrous)
Empirical Formula (Hill Notation): C20H21CaN7O7 · xH2O
Molecular Weight: 511.50 (anhydrous basis)
Linear Formula: C20H21CaN7O7 · xH2O
Product Type: Chemical
| agency |
EP |
| application(s) |
pharmaceutical (small molecule) |
| biological source |
synthetic |
| form |
solid |
| format |
neat |
| grade |
pharmaceutical primary standard |
| manufacturer/tradename |
EDQM |
| SMILES string |
[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13 |
| storage temp. |
−20°C |
| technique(s) |
gas chromatography (GC): suitable |
| |
liquid chromatography (LC): suitable |
| Application: |
Calcium folinate for system suitability may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography. |
| Application: |
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
| General description: |
Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil. |
| General description: |
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: |
Sales restrictions may apply. |
| Packaging: |
Unit quantity: 10 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Storage Temp. |
−20°C |
| UNSPSC |
41116107 |
GHS07,GHS08