Simvastatin for system suitability CRS
SUPELCO/Y0002069 - European Pharmacopoeia (EP) Reference Standard
Synonym: Simvastatin
CAS Number: 79902-63-9
Empirical Formula (Hill Notation): C25H38O5
Molecular Weight: 418.57
MDL Number: MFCD00072007
Linear Formula: C25H38O5
Product Type: Chemical
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C25H38O5/c1-6-25(4,5)2 |
InChI key | RYMZZMVNJRMUDD-HGQWONQESA |
manufacturer/tradename | EDQM |
mp | 127-132 °C (lit.) |
SMILES string | [H][C@]12[C@H](C[C@@H](C) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147). |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia . |
Other Notes: | Sales restrictions may apply. |
Packaging: | Unit quantity: 5 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
Symbol | GHS08 |
Signal word | Warning |
Hazard statements | H361d |
Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 127-132 °C (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 41116107 |