2-Deoxy-D-glucose
SUPELCO/PHR9231 - certified reference material, TraceCERT®
Synonym: 2-Deoxy-D-arabinohexose
CAS Number: 154-17-6
Empirical Formula (Hill Notation): C6H12O5
Molecular Weight: 164.16
MDL Number: MFCD00151328
Linear Formula: C6H12O5
Product Type: Chemical
grade | TraceCERT® |
certified reference material | |
InChI | 1S/C6H12O5/c7-2-1-4(9)6(1 |
InChI key | VRYALKFFQXWPIH-PBXRRBTRSA |
mp | 146-147 °C (lit.) |
product line | TraceCERT® |
Quality Level | 300 |
shelf life | limited shelf life, expiry date on the label |
SMILES string | OC[C@@H](O)[C@@H](O)[C@H] |
storage temp. | 2-8°C |
Biochem/physiol Actions: | 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK. |
General description: | This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich. |
Legal Information: | TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC |
mp | 146-147 °C (lit.) |
Storage Temp. | 2-8°C |