Triptolide

SUPELCO/PHL89811 - phyproof^® Reference Substance

Synonym: PG 490

CAS Number: 38748-32-2
Empirical Formula (Hill Notation): C₂₀H₂₄O₆
Molecular Weight: 360.40
MDL Number: MFCD00210565
Linear Formula: C₂₀H₂₄O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHL89811-10MG	10 mg	$584.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	food and beverages
assay	≥98.0% (HPLC)
format	neat
grade	primary reference standard
InChI	1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChI key	DFBIRQPKNDILPW-KTGKZQHOSA-N
manufacturer/tradename	PhytoLab
product line	phyproof^® Reference Substance
SMILES string	O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
storage temp.	2-8°C

Biochem/physiol Actions:	Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF_α) induction of apoptosis in part through the suppression of c-IAP₂ and c-IAP₁ induction.
General description:	This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Legal Information:	phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H330 - H361f
Precautionary statements	P201 - P301 + P310 + P330 - P304 + P340 + P310
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.0% (HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

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