Taxol
SUPELCO/PHL89806 - phyproof® Reference Substance
Synonym: Paclitaxel
CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C47H51NO14
Product Type: Chemical
assay | ≥95.0% (HPLC) |
form | solid |
grade | primary reference standard |
InChI | 1S/C47H51NO14/c1-25-31(60 |
InChI key | RCINICONZNJXQF-MZXODVADSA |
manufacturer/tradename | PhytoLab |
mp | 213 °C (dec.) (lit.) |
product line | phyproof® Reference Substance |
SMILES string | [H][C@@]12C[C@H](O)[C@@]3 |
storage temp. | −20°C |
Biochem/physiol Actions: | Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP). |
Caution: | Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions. |
General description: | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by Phytolab GmbH & Co. KG |
Legal Information: | phyproof is a registered trademark of PhytoLab GmbH & Co. KG |
Symbol | GHS05,GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372 |
Precautionary statements | P202 - P260 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
WGK Germany | WGK 3 |
Purity | ≥95.0% (HPLC) |
mp | 213 °C (dec.) (lit.) |
Storage Temp. | −20°C |
UNSPSC | 41116107 |