Synonym: 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one; Isodonol
CAS Number: 28957-04-2
Empirical Formula (Hill Notation): C20H28O6
Molecular Weight: 364.43
Linear Formula: C20H28O6
Product Type: Chemical
| application(s) |
food and beverages |
| assay |
≥98.0% (HPLC) |
| format |
neat |
| grade |
primary reference standard |
| manufacturer/tradename |
PhytoLab |
| product line |
phyproof® Reference Substance |
| Biochem/physiol Actions: |
Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells. |
| General description: |
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
| Legal Information: |
phyproof is a registered trademark of PhytoLab GmbH & Co. KG |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98.0% (HPLC) |
| UNSPSC |
41116107 |
