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3,3′,5-Triiodo-L-thyronine

SIGMA/T2877 - ≥95% (HPLC), powder

Synonym: O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; Liothyronine; T3

CAS Number: 6893-02-3
Empirical Formula (Hill Notation): C15H12I3NO4
Molecular Weight: 650.97
EC Number: 229-999-3
MDL Number: MFCD00002593
Linear Formula: C15H12I3NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T2877-100MG 100 mg
 $74.20
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45-T2877-250MG 250 mg
 $153.00
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45-T2877-500MG 500 mg
 $274.00
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45-T2877-1G 1 g
 $428.00
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45-T2877-5G 5 g
 $1570.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2877-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T2877-5G

 

assay ≥95% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI key AUYYCJSJGJYCDS-LBPRGKRZSA-N
mp 234-238 °C (lit.)
optical activity [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
Quality Level 200 
shipped in ambient
SMILES string N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
solubility 4 M NH4OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
sterility non-sterile
storage temp. −20°C
technique(s) transfection: suitable
Application: 3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.
Biochem/physiol Actions: 3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.
Other Notes: This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877 
Packaging: 1, 5 g in poly bottle
Packaging: 100, 250, 500 mg in poly bottle
Preparation Note: 3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
mp 234-238 °C (lit.)
Storage Temp. −20°C
UNSPSC 51111800

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