LAG-3 (mouse): FC (mouse)
SIGMA/SRP8041 - recombinant, expressed in CHO cells, >95% (SDS-PAGE)
Synonym: ACEH; FDC protein; Lymphocyte activation gene-3
Product Type: Chemical
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| assay | >95% (SDS-PAGE) |
| biological source | mouse |
| color | clear |
| concentration | ≥0.2 mg/mL |
| form | liquid |
| impurities | <1 EU/μg endotoxin, tested |
| mol wt | monomer ~180 kDa by SDS-PAGE (non-reducing) |
| monomer ~80 kDa by SDS-PAGE (reducing) | |
| packaging | pkg of 50 μg |
| recombinant | expressed in CHO cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | Q61790   |
| General description: | Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. |
| Other Notes: | The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3). |
| Physical form: | Solution in PBS. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |