IL-36β mouse
SIGMA/SRP8036 - recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
Synonym: Interleukin-1 family member 8; Interleukin-36β; Sentrin-specific protease 2
Product Type: Chemical
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| assay | >95% (SDS-PAGE) |
| biological source | mouse |
| color | white |
| conjugate | untagged |
| form | lyophilized |
| impurities | <0.01 EU/μg endotoxin, tested |
| mol wt | ~17 kDa |
| packaging | pkg of 10 μg |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | Q9D6Z6   |
| General description: | IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. |
| Other Notes: | IL-36beta (mouse) (aa 31-183) is untagged. |
| Physical form: | Lyophilized from PBS and 0.5% trehalose. |
| Preparation Note: | Reconstitute with 100 μL deionized water. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |