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Erlotinib hydrochloride

SIGMA/SML2156 - ≥98% (HPLC)

Synonym: 774 hydrochloride; CP-358; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride; OSI-744 hydrochloride

CAS Number: 183319-69-9
Empirical Formula (Hill Notation): C22H23N3O4 · HCl
Molecular Weight: 429.90
MDL Number: MFCD07781272
Linear Formula: C22H23N3O4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2156-50MG 50 mg
 $66.70
1/EA		 Add To Favorites
45-SML2156-100MG 100 mg
 $135.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChI key GTTBEUCJPZQMDZ-UHFFFAOYSA-N
SMILES string Cl.N(c3cc(ccc3)C#C)c1ncnc2c1cc(c(c2)OCCOC)OCCOC
solubility DMSO: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. −20°C
Application: Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.
Biochem/physiol Actions: EGFR kinase inhibitor; Antineoplastic
Biochem/physiol Actions: Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.
General description: Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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