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J104129 fumarate

SIGMA/SML1861 - ≥98% (HPLC)

Synonym: (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-penten-1-yl)-4-piperidinyl]-Benzeneacetamide fumarate; J-104129

CAS Number: 257603-40-0
Empirical Formula (Hill Notation): C24H36N2O2 · C4H4O4
Molecular Weight: 500.63
MDL Number: MFCD09753272
Linear Formula: C24H36N2O2 · C4H4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1861-5MG 5 mg
 $135.00
1/EA		 Add To Favorites
45-SML1861-25MG 25 mg
 $545.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H36N2O2.C4H4O4/c1-19(2)9-8-16-26-17-14-22(15-18-26)25-23(27)24(28,21-12-6-7-13-21)20-10-4-3-5-11-20;5-3(6)1-2-4(7)8/h3-5,9-11,21-22,28H,6-8,12-18H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+/t24-;/m0./s1
InChI key HUCQUCITPHOUAC-DSSYAJFBSA-N
optical activity [α]/D -6 to -8°, c = 1 in methanol
Quality Level 100 
SMILES string O=C(O)/C=C/C(O)=O.CC(C)=CCCN(CC1)CCC1NC([C@](C2CCCC2)(O)C3=CC=CC=C3)=O
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: J104129 is a muscarinic M3 receptor antagonist greater than 100-fold selectivity for M3 over M2 receptors. Its Ki for M3 receptors = 4.2 nM compared to a Ki of 490 nM for M2 receptors. J-104129 showed potent bronchodilator activity in animal studies.
Biochem/physiol Actions: Potent M3 muscarinic receptor antagonist with > 120-fold selectivity over M2 receptors
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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