Synonym: (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one; 1(R),10(S)-Epoxy-5(S),5(S),7(S)-guaia-3(4),11(13)-dien-6,12-olide
CAS Number: 84692-91-1
Empirical Formula (Hill Notation): C15H18O3
Molecular Weight: 246.30
Linear Formula: C15H18O3
Product Type: Chemical
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| assay |
≥98% (HPLC) |
| biological source |
semisynthetic (from parthenolide) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C15H18O3/c1-8-4-7-15-11(8)12-10(9(2)13(16)17-12)5-6-14(15,3)18-15/h4,10-12H,2,5-7H2,1,3H3/t10-,11-,12-,14-,15+/m0/s1 |
| InChI key |
UVJYAKBJSGRTHA-ZCRGAIPPSA-N |
| Quality Level |
100  |
| SMILES string |
O1[C@@]32[C@@]1(CC[C@@H]4[C@H](OC(=O)C4=C)[C@@H]3C(=CC2)C)C |
| storage condition |
protect from light |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Arglabin is a natural product with antitumor and anti-inflammatory activity. Arglabin competitively inhibits the binding of farnesyl diphosphate to farnesyl transferase (FTase), preventing the activation of RAS proto-oncogene by preventing the incorporation of farnesyl pyrophosphate into human H-ras proteins. Arglabin is also an inhibitor of the NLRP3 inflammasome. Arglabin reduces inflammation and plasma lipids and has shown a marked reduction in atherosclerotic lesions. |
| Packaging: |
1, 5 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |