(±)-Marinopyrrole A
SIGMA/SML1533 - ≥95% (HPLC)
Synonym: (±)-Maritoclax; 1,1′-(4,4′,5,5′-Tetrachloro[1,3′-bi-1H-pyrrole]-2,2′-diyl)bis[1-(2-hydroxyphenyl)-methanone
CAS Number: 1227962-62-0
Empirical Formula (Hill Notation): C22H12Cl4N2O4
Molecular Weight: 510.15
Linear Formula: C22H12Cl4N2O4
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1533-25MG.
This image depicts SML1533-25MG.
| assay | ≥95% (HPLC) |
| color | light yellow to dark yellow |
| form | powder |
| InChI | 1S/C22H12Cl4N2O4/c23-12-9 |
| InChI key | QYPJBTMRYKRTFG-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Clc1[n](c(cc1Cl)C(=O)c4c( |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737. |
| Biochem/physiol Actions: | Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1; antibiotic. |
| General description: | Marinopyrrole A (Maritoclax) is a member of phenolic 1,3′-bipyrroles family targeting actin group. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard statements | H413 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |