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Cinaciguat hydrochloride

SIGMA/SML1532 - ≥98% (HPLC)

Synonym: 4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride; 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride; BAY 58-2667 hydrochloride; BAY582667 hydrochloride; UNII-59K0Y58UAD hydrochloride

CAS Number: 646995-35-9
Empirical Formula (Hill Notation): C36H39NO5 · HCl
Molecular Weight: 602.16
MDL Number: MFCD28127267
Linear Formula: C36H39NO5 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1532-5MG 5 mg
 $269.00
1/EA		 Add To Favorites
45-SML1532-25MG 25 mg
 $1070.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1532-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H
InChI key LLHMBJOVHATVSP-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO.
Biochem/physiol Actions: Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.
Biochem/physiol Actions: Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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