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SID 3712249

SIGMA/SML1518 - ≥95% (HPLC)

Synonym: 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile; MLS000054131; MiR-544 Inhibitor 1

CAS Number: 522606-67-3
Empirical Formula (Hill Notation): C17H21N7
Molecular Weight: 323.40
MDL Number: MFCD03483890
Linear Formula: C17H21N7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1518-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-SML1518-25MG 25 mg
 $365.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1518-25MG.

 

assay ≥95% (HPLC)
color white to brown
form powder
InChI 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
InChI key SSWVPYMSHHEYAB-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
solubility DMSO: 15 mg/mL, clear
storage condition protect from light
storage temp. room temp
Biochem/physiol Actions: SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544).
Biochem/physiol Actions: SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
Other Notes: light sensitive
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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