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SR9243

SIGMA/SML1517 - ≥98% (HPLC)

Synonym: N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)benzenesulfonamide

CAS Number: 1613028-81-1
Empirical Formula (Hill Notation): C31H32BrNO4S2
Molecular Weight: 626.62
MDL Number: MFCD29049514
Linear Formula: C31H32BrNO4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1517-5MG 5 mg
 $119.00
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This image depicts SML1517-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C31H32BrNO4S2/c1-22-17-23(2)31(24(3)18-22)39(36,37)33(16-15-25-7-5-9-29(32)19-25)21-26-11-13-27(14-12-26)28-8-6-10-30(20-28)38(4,34)35/h5-14,17-20H,15-16,21H2,1-4H3
InChI key FYQFEJFTCLKXTQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=CC(C)=C(S(N(CCC2=CC=CC(Br)=C2)CC3=CC=C(C4=CC(S(C)(=O)=O)=CC=C4)C=C3)(=O)=O)C(C)=C1
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: SR9243 has the ability to reduce liver fibrosis stimulated by BDL (bile-duct ligation) and CCL4 (carbon tetrachloride). It stimulates apoptosis without promoting weight loss, hepatotoxicity and inflammation. SR9243 blocks the initiation of liver-X-receptor (LXR) by increasing LXR-corepressor recruitment.
Biochem/physiol Actions: SR9243 is a selective inverse agonist of the nuclear receptor liver-X-receptor (LXR) that targets the Warburg effect, inhibiting glycolysis and lipogenesis by reducing glycolytic and lipogenic gene expression. SR9243 is believed to enhance corepressor recruitment to LXRs at target-gene promoters, resulting in suppression of gene expression. SR9243 induced apoptosis in tumor cells without harming normal cells. SR9243 reduced prostate, colorectal, and lung cancer cell viability at nanomolar concentrations and also inhibited colon tumor xenograft growth.
Biochem/physiol Actions: SR9243 is a selective inverse agonist of the nuclear receptor liver-X-receptor (LXR).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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