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NMS-873

SIGMA/SML1128 - ≥98% (HPLC)

Synonym: 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-pyridine; 3-[3-Cyclopentylsulfanyl-5-(4′-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine

CAS Number: 1418013-75-8
Empirical Formula (Hill Notation): C27H28N4O3S2
Molecular Weight: 520.67
MDL Number: MFCD28009371
Linear Formula: C27H28N4O3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1128-5MG 5 mg
 $173.00
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45-SML1128-25MG 25 mg
 $655.00
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This image depicts SML1128-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
InChI key UJGTUKMAJVCBIS-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=CC(OCC2=NN=C(SC3CCCC3)N2C4=CN=CC=C4)=CC=C1C5=CC=C(S(C)(=O)=O)C=C5
solubility DMSO: 25 mg/mL, clear
storage temp. 2-8°C
Application: MS-873 has been used as an allosteric inhibitor of ATPase valosin-containing protein (VCP)/p97.
Biochem/physiol Actions: NMS-873 is a selective allosteric non–ATP-competitive inhibitor of the AAA ATPase family member valosine containing protein (VCP), also known as p97 (VCP/p97), an integral component of the ubiquitin fusion degradation (UFD) pathway. VCP/p97 plays a role in degradation of misfolded proteins, Golgi membrane reassembly, membrane transport, myofibril assembly, autophagosome maturation, and cell division, and is overexpressed in many tumor types. NMS-873 is the most potent and specific VCP inhibitor described to date. NMS-873 has an IC50 of 30 nM for VCP/p97 compared to IC50 >10 μM against all of the AAA ATPases, HSP90 or the 53 kinases analyzed. NMS-873 inhibited proliferation of HCT116 cancer cell line cells with an IC50 value of 400 nM.
Biochem/physiol Actions: NMS-873 is a selective allosteric non–ATP-competitive inhibitor of the AAA ATPase family member valosine containing protein (VCP), also known as p97 (VCP/p97).
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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