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Thiophene-2

SIGMA/SML1120 - ≥98% (HPLC)

Synonym: Methyl 2-(perfluorobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate; TP2

CAS Number: 420089-51-6
Empirical Formula (Hill Notation): C18H14F5NO3S
Molecular Weight: 419.37
MDL Number: MFCD01337175
Linear Formula: C18H14F5NO3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1120-5MG 5 mg
 $111.00
1/EA		 Add To Favorites
45-SML1120-25MG 25 mg
 $356.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1120-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H14F5NO3S/c1-27-18(26)9-7-5-3-2-4-6-8(7)28-17(9)24-16(25)10-11(19)13(21)15(23)14(22)12(10)20/h2-6H2,1H3,(H,24,25)
InChI key AVRWEULSKHQETA-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(OC)C1=C(NC(C2=C(F)C(F)=C(F)C(F)=C2F)=O)SC3=C1CCCCC3
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Thiophene-2 (TP2) is an inhibitor of polyketide synthase 13 (Pks13), which plays a critical role in the biosynthesis of mycolic acid, an essential component of the cell wall in M. tuberculosis, and is a potential new target for tuberculosis treatment. TP2 inhibits FadD32-dependent loading of the mycolic acid precursor meromycoloyl chain onto acyl carrier protein (ACP) domains located at the N terminus of Pks13, preventing synthesis of mycolic acid and resulting in mycobacterial cell death. TP2 bacteriosidal activity is equivalent to treatment with the first-line drug isoniazid, and enhances its activity, but is less likely to cause resistance. The minimal inhibitory concentration (MIC) values of TP2 against drug-susceptible multidrug-resistant M. tuberculosis strains is approximately 1 μM.
Biochem/physiol Actions: Thiophene-2 (TP2) is an inhibitor of polyketide synthase 13 (Pks13).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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