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Ethacrynic acid

SIGMA/SML1083 - ≥97% (HPLC)

Synonym: 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid; ECA; Etacrynic acid; [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid; (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

CAS Number: 58-54-8
Empirical Formula (Hill Notation): C13H12Cl2O4
Molecular Weight: 303.14
EC Number: 200-384-1
MDL Number: MFCD00056693
Linear Formula: C13H12Cl2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1083-10MG 10 mg
 $48.00
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assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChI key AVOLMBLBETYQHX-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.
Biochem/physiol Actions: Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.
Packaging: 10 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352106

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