CHIR99021

SIGMA/SML1046 - ≥98% (HPLC)

Synonym: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CT99021

CAS Number: 252917-06-9
Empirical Formula (Hill Notation): C₂₂H₁₈Cl₂N₈
Molecular Weight: 465.34
MDL Number: MFCD11846251
Linear Formula: C₂₂H₁₈Cl₂N₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1046-5MG	5 mg	$127.00 1/EA	Add To Favorites
45-SML1046-25MG	25 mg	$512.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML1046-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
InChI key	AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Quality Level	100
SMILES string	ClC(C=C1Cl)=CC=C1C2=NC(NCCNC(N=C3)=CC=C3C#N)=NC=C2C4=NC(C)=CN4
solubility	DMSO: 2 mg/mL, clear (warmed)
storage temp.	−20°C

Application:	CHIR99021 has been used as a Wnt signaling agonist to study its effects on the differentiation of human pluripotent stem cell-derived cardiomyocytes (hPSCs).
Application:	CHIR99021 has been used: • in cocktail with small molecules to convert human lung fibroblast cells into neurons • as a culture medium supplement in potassium supplemented simplex optimization medium (KSOM) for the culture of blastocysts • for chronic inhibition of GSK-3 to investigate its role in corticogenesis
Biochem/physiol Actions:	CHIR99021 is a very potent inhibitor of Glycogen synthase kinase 3 (GSK3, IC₅₀ values for GSK3α and GSK3β = 10 and 6.7 nM, respectively). There is no cross-reactivity against CDKs. CHIR99201 potentiates self-renewal of human and mouse embryonic stem cells, and enhances reprogramming of somatic cells into stem cells.
Biochem/physiol Actions:	CHIR99021 is a very potent inhibitor of Glycogen synthase kinase 3.
General description:	CHIR99021 is an aminopyrimidine derivative. CHIR99021 promotes self-renewal potential of embryonic stem cells (ESCs) of mice by inhibiting glycogen synthase kinase-3 (GSK-3) activity and potentiates the upregulation of β-catenin and c-Myc functions. CHIR99021 promotes self-renewal of ESCs by modulating transforming growth factor β (TGF-β), Notch and mitogen-activated protein kinases (MAPK) signaling pathways. CHIR99021 is an agonist of wingless/integrated (wnt) signalling, upregulates cyclinA expression and promotes cell proliferation in non-small-cell lung cancer (NSCLC) cell lines.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 - H315 - H319 - H335
Precautionary statements	P261 - P264 - P301 + P310 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	25-36/37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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