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KC7F2

SIGMA/SML1043 - ≥98% (HPLC)

Synonym: N,N′-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide

CAS Number: 927822-86-4
Empirical Formula (Hill Notation): C16H16Cl4N2O4S4
Molecular Weight: 570.38
MDL Number: MFCD22683809
Linear Formula: C16H16Cl4N2O4S4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1043-1MG 1 mg
 $51.20
1/EA		 Add To Favorites
45-SML1043-5MG 5 mg
 $84.60
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1043-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
InChI key REQLACDIZMLXIC-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string ClC1=CC=C(Cl)C=C1S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: KC7F2 is a cell permeable potent HIF-1 pathway inhibitor.
Biochem/physiol Actions: KC7F2 is a cell permeable potent HIF-1 pathway inhibitor. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1? in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: air sensitive
Packaging: 1, 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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