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NSC 617145

SIGMA/SML1005 - ≥98% (HPLC)

Synonym: (2,3-Propandiyl-bis(2,3-dichloro)maleimide; 1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione; NSC-617145; SID 487795

CAS Number: 203115-63-3
Empirical Formula (Hill Notation): C13H10Cl4N2O4
Molecular Weight: 400.04
Linear Formula: C13H10Cl4N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1005-5MG 5 mg
 $139.00
1/EA		 Add To Favorites
45-SML1005-25MG 25 mg
 $525.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
InChI key PCOXPBOKDABARQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=C(C(=O)N(C1=O)CC(CN2C(=O)C(=C(C2=O)Cl)Cl)(C)C)Cl
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: NSC 617145 has an IC50 value of 230nM.
Biochem/physiol Actions: NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) that causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells.
Biochem/physiol Actions: NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN).
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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