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GSK2193874

SIGMA/SML0942 - ≥98% (HPLC)

Synonym: 3-([1,4′-Bipiperidin]-1′-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

CAS Number: 1336960-13-4
Empirical Formula (Hill Notation): C37H38BrF3N4O
Molecular Weight: 691.62
Linear Formula: C37H38BrF3N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0942-5MG 5 mg
 $121.00
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45-SML0942-25MG 25 mg
 $491.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
InChI key UIVOZBSCHXCGPS-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)c1cc(ccc1)c2nc3c(c(c2CN6CCC(CC6)N7CCCCC7)C(=O)NC5(CC5)c4ccccc4)ccc(c3)Br
solubility DMSO: >5 mg/mL, clear
storage temp. room temp
Application: GSK2193874 has been used as a transient receptor potential vanilloid 4 (TRPV4) antagonist:
• to study its effects on GSK101-induced colon contractions in mice
• to study its effects on murine compact bone-derived osteoblasts(CB-OB)
• to study its effects on lung injury post-lipopolysaccharide (LPS) in mice
Biochem/physiol Actions: GSK2193874 is a very potent, specific antagonist of TRPV4 ion channels (IC50 = 50 nM). Lung edema caused by high pulmonary venous pressure (PVP) is driven by TRPV4 activity. GSK2193874 blocks TRPV4-mediated calcium influx in cells expressing native and recombinant TRPV4, and inhibits vascular permeability and lung edema in isolated rodent and canine lungs subjected to high PVP. The compound also resolves pulmonary edema in murine myocardial infarction model.
Biochem/physiol Actions: GSK2193874 is a very potent, specific antagonist of TRPV4.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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