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bpV(HOpic)

SIGMA/SML0884 - ≥90% V basis

Synonym: Bisperoxovanadium(HOpic); Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V); K2[VO(O2)2C6H4NO3]

CAS Number: 722494-26-0
Empirical Formula (Hill Notation): K2VOO2O2C6H4NO3
Molecular Weight: 347.24
Linear Formula: K2VOO2O2C6H4NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0884-5MG 5 mg
 $107.00
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45-SML0884-25MG 25 mg
 $431.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥90% V basis
color faintly yellow to dark yellow
form powder
InChI 1S/C6H5NO3.2K.2O2.4H2O.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;;;;;/h2-3H,1H2,(H,9,10);;;;;4*1H2;;/q;2*+1;2*-2;;;;;-1;+4/p-1
InChI key HSCJTESZNNRNPK-UHFFFAOYSA-M
Quality Level 100 
SMILES string [V]32(OO3)(OO2)([NH]1=CC(=O)CC=C1C(=O)[O-])[O-].[K+].[K+].O.O.O.O
solubility H2O: 20 mg/mL, clear
storage condition desiccated
  protect from light
storage temp. −20°C
Application: bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.
Biochem/physiol Actions: bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 μM for PTPβ and 25.3 μM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.
Biochem/physiol Actions: bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.
Other Notes: Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319
Precautionary statements P302 + P352 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% V basis
Storage Temp. −20°C
UNSPSC 12352200

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