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CRANAD 2

SIGMA/SML0842 - ≥98% (HPLC)

Synonym: (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron

CAS Number: 1193447-34-5
Empirical Formula (Hill Notation): C23H25BF2N2O2
Molecular Weight: 410.26
Linear Formula: C23H25BF2N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0842-5MG 5 mg
 $135.00
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45-SML0842-25MG 25 mg
 $527.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color , dark blue to black
form powder
InChI 1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+
InChI key PVXQJYXODFZTBR-KAVGSWPWSA-N
Quality Level 100 
SMILES string [B-]1([O+]=C(C=C(O1)C=Cc3ccc(cc3)N(C)C)C=Cc2ccc(cc2)N(C)C)(F)F
solubility DMSO: 0.2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe.
Biochem/physiol Actions: CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, CRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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