A 83-01
SIGMA/SML0788 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 909910-43-6
Empirical Formula (Hill Notation): C25H19N5S
Molecular Weight: 421.52
Linear Formula: C25H19N5S
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0788-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0788-5MG
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C25H19N5S/c1-17-8-7-13 |
| InChI key | HIJMSZGHKQPPJS-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | S=C([n]2nc(c(c2)c4c5c(ncc |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Application: | A 83-01 has been used as an inhibitor of transforming growth factor β kinase type 1 receptor. |
| Application: | A 83-01 has been used: • in the culture medium for organoid formation from dissociated tumor cells, • as a component in Dulbecco′s modified Eagle medium/nutrient mixture F-12 (DMEM/F12) for culturing human epidermal stem cells (EpSCs) |
| Biochem/physiol Actions: | A 83-01 is a TGFβ kinase/activin receptor-like kinase (ALK 5) inhibitor (IC50=12 nM) that prevents phosphorylation of Smad2/3 and inhibits growth induced by TGFβ. A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Also, A 83-01 inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7. A-83-01 induces an expansion of neonatal Nkx2.5-eGFP (+) cells. |
| Biochem/physiol Actions: | A-83-01 is a TGFβ kinase/activin receptor-like kinase (ALK 5) inhibitor. |
| General description: | A-83-01 may effectively prevent burn wound contraction without impeding wound closure, due to its ability to inhibit the transforming growth factor-β (TGF-β)-induced rise in myofibroblast population. Additionally, it can hinder TGF-β1-dependent cancer metastasis by suppressing epithelial-mesenchymal transition (EMT) in animals. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 - P337 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |