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TPPU

SIGMA/SML0750 - ≥98% (HPLC)

Synonym: 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea; N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

CAS Number: 1222780-33-7
Empirical Formula (Hill Notation): C16H20F3N3O3
Molecular Weight: 359.34
Linear Formula: C16H20F3N3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0750-5MG 5 mg
 $126.00
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45-SML0750-25MG 25 mg
 $496.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C16H20F3N3O3/c1-2-14(23)22-9-7-12(8-10-22)21-15(24)20-11-3-5-13(6-4-11)25-16(17,18)19/h3-6,12H,2,7-10H2,1H3,(H2,20,21,24)
InChI key AAJMQTLFRTZCJK-UHFFFAOYSA-N
Quality Level 100 
SMILES string FC(F)(F)Oc1ccc(cc1)NC(=O)NC2CCN(CC2)C(=O)CC
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: TPPU has been used as a soluble epoxide hydrolase (SEH) inhibitor to characterize its pharmacokinetic (PK) and pharmacodynamic properties in rodents. It has also been used as a SEH inhibitor to study its effects on 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) concentrations in nervous tissues.
Biochem/physiol Actions: TPPU is a potent sEH inhibitor (IC50 = 3.7 nM) that has been shown to have very favorable PK attributes in cynomolgus monkeys. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyiecosatrienoic acids (DHETs), and sEH inhibitors display anti-inflammatory and anti-atherosclerotic effects.
Biochem/physiol Actions: TPPU is a potent sEH inhibitor.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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