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FSLLRY-NH2 trifluoroacetate salt

SIGMA/SML0714 - ≥98% (HPLC)

CAS Number: 245329-02-6 (free base)
Empirical Formula (Hill Notation): C39H60N10O8 · xC2HF3O2
Molecular Weight: 796.96 (free base basis)
Linear Formula: C39H60N10O8 · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0714-1MG 1 mg
 $122.00
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
InChI key KMSCNWHRNILNRJ-JNRWAQIZSA-N
Quality Level 100 
shipped in wet ice
SMILES string N([C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N)C(=O)[C@@H](N)Cc1ccccc1
storage temp. −20°C
Amino Acid Sequence: Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt
Application: FSLLRY-NH2 trifluoroacetate salt has been used as a protease-activated receptor 2 (PAR2) inhibitor to test its effects on urinary tract infections (UTIs) in a murine model. It has also been used to study the clinical itch datasets from phase 3 clinical trials for moderate-to-severe AD in atopic dermatitis (AD)-associated acute itch flare mice modelin rats.
Biochem/physiol Actions: FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2).
Biochem/physiol Actions: FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells.
Biochem/physiol Actions: The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests that PAR2 is involved in the maintenance of VH.
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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