Ro 41-5253
SIGMA/SML0573 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 144092-31-9
Empirical Formula (Hill Notation): C28H36O5S
Molecular Weight: 484.65
Linear Formula: C28H36O5S
Product Type: Chemical
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This image depicts SML0573-5MG.
This image depicts SML0573-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C28H36O5S/c1-5-6-7-8-9 |
| InChI key | JEIWQRITHXYGIF-LVZFUZTISA |
| Quality Level | 100  |
| SMILES string | [S]1(=O)(=O)CCC(c2c1cc(c( |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Ro 41-5253 has been used as a retinoic acid receptor-α (RAR-α) antagonist to study its effect on hepatitis B virus (HBV) infection. |
| Biochem/physiol Actions: | Ro 41-5253 ( GR110) is a potent (IC50 = 16 nM) and selective retinoic acid receptor-α (RARα) antagonist, with some recently discovered activity as a PPARγ agonist at 50-fold higher concentrations (EC50 = 810 nM). |
| Biochem/physiol Actions: | Ro 41-5253 ( GR110) is a potent (IC50 = 16 nM) and selective retinoic acid receptor-α (RARα) antagonist, with some recently discovered activity as a PPARγ agonist at 50-fold higher concentrations (EC50 = 810 nM). Ro 41-5253 inhibited differentiation and prevented the loss of human HSCs that otherwise occurs in short-term culture. |
| Biochem/physiol Actions: | Ro 41-5253 is a member of an interesting class of retinoids with anti-proliferative properties. It can repress the activity of retinoic acid receptor-α (RAR-α) in rat embryonic gonad culture. Ro 41-5253 can decrease the expression stimulated by the retinoic acid gene 8 (STRA8) gene. It can prevent multiplication and stimulate apoptosis in breast cancer cell lines. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |