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LY-411575

SIGMA/SML0506 - ≥97% (HPLC)

Synonym: LSN-411575; LY 411575; N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide

CAS Number: 209984-57-6
Empirical Formula (Hill Notation): C26H23F2N3O4
Molecular Weight: 479.48
MDL Number: MFCD09832551
Linear Formula: C26H23F2N3O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0506-5MG 5 mg
 $142.00
1/EA		 Add To Favorites
45-SML0506-25MG 25 mg
 $566.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0506-5MG.

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChI key ULSSJYNJIZWPSB-CVRXJBIPSA-N
Quality Level 100 
shipped in wet ice
SMILES string C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24
solubility DMSO: 5 mg/mL, clear
storage temp. −20°C
Application: LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.
Biochem/physiol Actions: LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
Biochem/physiol Actions: LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ40/42 after acute or chronic treatment, and blocks Notch activation.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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