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Carboxyamidotriazole

SIGMA/SML0408 - ≥98% (HPLC)

Synonym: 5-Amino-1-[[3,5-Dichloro-4-(4-chlorobenzoyl)phenyl]meth yl]-1H-1,2,3-triazole-4-carboxamide; CAI; L-651582

CAS Number: 99519-84-3
Empirical Formula (Hill Notation): C17H12Cl3N5O2
Molecular Weight: 424.67
MDL Number: MFCD00866325
Linear Formula: C17H12Cl3N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0408-5MG 5 mg
 $109.00
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45-SML0408-25MG 25 mg
 $293.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0408-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27)
InChI key WNRZHQBJSXRYJK-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC(=O)c1nnn(Cc2cc(Cl)c(c(Cl)c2)C(=O)c3ccc(Cl)cc3)c1N
solubility DMSO: 10 mg/mL (clear solution)
storage temp. 2-8°C
Biochem/physiol Actions: Carboxyamidotriazole (CAI) is a non-cytotoxic anticancer drug. It exhibits anti-inflammatory properties and reduces the release of proinflammatory cytokines. CAI prevents the proliferation and invasive behavior of a variety of human cancer cell types and endothelial cells in vitro and in vivo. It is used to treat several acute and chronic inflammation models, like adjuvant arthritis and inflammatory bowel diseases (IBD). CAI blocks tumor cell proliferation and stimulates cell apoptosis in vitro.
Biochem/physiol Actions: Carboxyamidotriazole (L-651582) is an orally active calcium channel blocker. Carboxyamidotriazole blocks intracellular and mitochondrial calcium entry and flux, resulting in inhibition of cell proliferation, calcium-release-activated calcium channel (CRAC) function, and maintenance of mitochondrial membrane potential.
Biochem/physiol Actions: Carboxyamidotriazole is a calcium channel blocker/calcium flux inhibitor; inhibits CRAC channel function.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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