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Edelfosine

SIGMA/SML0332 - ≥95% (HPLC)

Synonym: 1-Octadecyl-2-methylglycero-3-phosphorylcholine; 4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-Trioxa-4-phosphaheptacosan-1-aminium 4-oxide; ALP; ET 18-OCH3; ET-18-OMe; NSC 324368; NSC 343649; Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine; Ro 14-5243

CAS Number: 70641-51-9
Empirical Formula (Hill Notation): C27H58NO6P
Molecular Weight: 523.73
MDL Number: MFCD00135190
Linear Formula: C27H58NO6P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0332-5MG 5 mg
 $166.00
1/EA		 Add To Favorites
45-SML0332-25MG 25 mg
 $626.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0332-5MG.

 

assay ≥95% (HPLC)
color white to beige
form powder
InChI 1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3
InChI key MHFRGQHAERHWKZ-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string CCCCCCCCCCCCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)OC
solubility H2O: 15 mg/mL (clear solution)
storage temp. −20°C
Application: Edelfosine has been used to treat human lung carcinoma A549 cells and study its effects on tuftelin 1 (TUFT1) expression. It is also used to evaluate the cell growth of MCF-7/M cells.
Biochem/physiol Actions: Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity.
Biochem/physiol Actions: Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity. The compound induces apoptosis in a variety of cancer cells. Edelfosine accumulates in the cell membrane, where it alters lipid composition and induces the co-clustering of lipid rafts and Fas/CD95 death receptor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Edelfosine has anti-inflammatory, anti-autoimmune, antiparasitic and anti-viral properties. It stimulates eryptosis by cell shrinkage and cell membrane scrambling.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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