SR1001
SIGMA/SML0322 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1335106-03-0
Empirical Formula (Hill Notation): C15H13F6N3O4S2
Molecular Weight: 477.40
MDL Number: MFCD23160036
Linear Formula: C15H13F6N3O4S2
Product Type: Chemical
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This image depicts SML0322-5MG.
This image depicts SML0322-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H13F6N3O4S2/c1-7-11 |
| InChI key | OZBSSKGBKHOLGA-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(=O)Nc1nc(C)c(s1)S(=O)( |
| solubility | DMSO: >5 mg/mL |
| storage temp. | 2-8°C |
| Application: | SR1001 has been used as retinoic-acid receptor (RAR)-related orphan nuclear receptor gamma (RORγt) inhibitor to study its effects on interleukin 17 (IL-17) expression in itch cells , as a RAR-related orphan receptor alpha (RORα)- inhibitor to study its effects on RORα-dependent transcription of glucose-6-phosphatase (G6Pase) . |
| Application: | SR1001 has been used for inhibiting retinoid-related orphan receptor-γ t (RORγT) activation in Itch−/− mice. |
| Biochem/physiol Actions: | SR1001 is a RORα/RORγt antagonist with no activity at LXR or RORβ; suppressor of TH17 cell differentiation and autoimmunity. |
| Biochem/physiol Actions: | SR1001 is an antagonist of the nuclear retinoic acid receptor-related orphan receptors RORα and RORγt with no activity at LXR or RORβ. RORα and RORγt are essential for the development of TH17 cells, T-helper cells that produce interleukin-17 and have recently been shown to have pathological roles in various autoimmune diseases. SR1001 binds to the ligand-binding domain of RORα and RORγt to decrease affinity of the receptor for coactivators and increse affinity for co-repressors. It inhibited the differentiation and function of TH17 cells and suppressed the clinical severity of a mouse model of multiple sclerosis. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H319 |
| Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |