AEG 3482

SIGMA/SML0264 - ≥98% (HPLC)

Synonym: 6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

CAS Number: 63735-71-7
Empirical Formula (Hill Notation): C₁₀H₈N₄O₂S₂
Molecular Weight: 280.33
MDL Number: MFCD02064987
Linear Formula: C₁₀H₈N₄O₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0264-5MG	5 mg	$122.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	faintly yellow to dark yellow
form	powder
InChI	1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChI key	MQUYTXDAVCOCMX-UHFFFAOYSA-N
Quality Level	100
SMILES string	NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3
solubility	DMSO: ≥15 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
Biochem/physiol Actions:	AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
Biochem/physiol Actions:	AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
Features and Benefits:	This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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