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HC-067047

SIGMA/SML0143 - ≥98% (HPLC)

Synonym: 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

CAS Number: 883031-03-6
Empirical Formula (Hill Notation): C26H28F3N3O2
Molecular Weight: 471.51
MDL Number: MFCD01571257
Linear Formula: C26H28F3N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0143-5MG 5 mg
 $117.00
1/EA		 Add To Favorites
45-SML0143-25MG 25 mg
 $472.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
InChI key NCZYSQOTAYFTNM-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
solubility DMSO: ≥15 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: HC-067047 has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) inhibitor:
• to study its effects on organoid formation and proliferation in human endometrial tissues
• to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
• to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus
Biochem/physiol Actions: HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC50 values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC50 values of 370 and 780 nM, respectively.
Biochem/physiol Actions: HC-067047 is a TRPV4 antagonist
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25-36
Safety Statements 26-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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