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NMQ/N-methyl-quinidine - MDR1/P-gp Substrate

SIGMA/SBNMQ

Synonym: SB-NMQ; N-methyl-quinidine (NMQ); NMQ

CAS Number: 42982-87-6
Empirical Formula (Hill Notation): C21H27IN2O2
Molecular Weight: 466.36
Linear Formula: C21H27IN2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SBNMQ-5MG 5 mg
 $177.00
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45-SBNMQ-10MG 10 mg
 $265.00
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45-SBNMQ-50MG 50 mg
 $389.00
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45-SBNMQ-100MG 100 mg
 $527.00
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45-SBNMQ-500MG 500 mg
 $1280.00
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45-SBNMQ-1G 1 g
 $2290.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

color white
form powder
InChI 1S/C21H27N2O2.HI/c1-4-14-13-23(2)10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-3)12-18(17)19;/h4-7,9,12,14-15,20-21,24H,1,8,10-11,13H2,2-3H3;1H/q+1;/p-1/t14-,15?,20+,21-,23?;/m0./s1
InChI key AJQSDVGBERUTGX-QVEQJUGRSA-M
SMILES string [I-].[N+]21([C@H](CC([C@H](C2)C=C)CC1)[C@@H](O)c3c4c(ncc3)ccc(c4)OC)C
storage temp. room temp
Application: NMQ/N-methyl-quinidine - MDR1/P-gp substrate has been used as a probe substrate for multidrug resistance protein 1 (MDR1) in vesicles assay.
Biochem/physiol Actions: SOLVO Biotechnology offers NMQ as a selective substrate for the MDR1 membrane transporter.

NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. room temp
UNSPSC 12352200

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