Glucose-6-phosphate Isomerase human
SIGMA/SAE0005 - recombinant, expressed in E. coli
Synonym: GPI; PGI
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| specific activity | ≥200 units/mg protein |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment. |
| General description: | C-terminal histidine-tagged |
| Other Notes: | One unit will convert 1.0 mmole of |
| Physical form: | Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| activity | specific activity: ≥200 units/mg protein |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 5.3.1.9 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |