Anti-phospho-PKR (pThr446) antibody produced in rabbit
SIGMA/SAB4504517 - affinity isolated antibody
Synonym: Anti-DYT33; Anti-EIF2AK1; Anti-LEUDEN; Anti-PKR; Anti-PPP1R83; Anti-PRKR
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma.
Immunohistochemistry Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Immunohistochemistry analysis of paraffin-embedded Human kidney carcinoma.
Immunohistochemistry Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Immunohistochemistry analysis of paraffin-embedded Human liver carcinoma.
Immunohistochemistry Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Immunohistochemistry analysis of paraffin-embedded Human prostate carcinoma.
Immunohistochemistry Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue.
Western Blotting Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: Western blot analysis of extracts from NIH-3T3 cells treated with 2500 U/mL IFN for 30 minutes.
ELISA Anti-phoshpho-PKR (pThr446): Cat. No. SAB4504517: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 62 kDa |
| NCBI accession no. | P19525   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr446) |
| technique(s) | ELISA: 1:10000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P19525 |
| Biochem/physiol Actions: | EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferons. This gene is involved in stress responses and inflammation pathways. This gene controls the development and multiplication of cells, nutrient signaling and metabolism. EIF2AK2 also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2αfamily of protein kinases. PKR contains two RNA binding domains and a kinase domain. This gene is located on human chromosome 2p22-p21. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446. Immunogen Range: 413-462 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |