Anti-phospho-PLB (pSer16+Thr17) antibody produced in rabbit
SIGMA/SAB4503970 - affinity isolated antibody
Product Type: Chemical
Immunohistochemistry Anti-phoshpho-PLB (pSer16+Thr17): Cat. No. SAB4503970: Immunohistochemistry analysis of paraffin-embedded Human kidney carcinoma.
Immunohistochemistry Anti-phoshpho-PLB (pSer16+Thr17): Cat. No. SAB4503970: Immunohistochemistry analysis of paraffin-embedded Human lung carcinoma.
Immunohistochemistry Anti-phoshpho-PLB (pSer16+Thr17): Cat. No. SAB4503970: Immunohistochemistry analysis of paraffin-embedded Human ovary carcinoma.
ELISA Anti-phoshpho-PLB (pSer16)+Thr17): Cat. No. SAB4503970: ELISA for Immunogen Phosphope(pTide (left) and Non-Phosphope(pTide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 6 kDa |
| NCBI accession no. | P26678   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer16/pThr17) |
| technique(s) | ELISA: 1:1000 |
| immunofluorescence: 1:100-1:500 | |
| UniProt accession no. | P26678 |
| Biochem/physiol Actions: | Phospholamban (PLN) participates in calcium signalling and muscle contraction. This protein regulates the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) of cardiac myocytes. Mutations in the phospholamban (PLN) gene result in dilated cardiomyopathy (DCM) and severe heart failure. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Phospholamban (PLN) gene codes for a small integral membrane protein. It is located on human chromosome 6q22.1. PLN is a 52-amino-acid phosphoprotein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17. Immunogen Range: 1-50 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |