Anti-LOR
SIGMA/SAB2108557 - IgG fraction of antiserum
Synonym: Anti-MGC111513
Product Type: Product-on-demand
Immunohistochemistry Anti-LOR: Cat. No. AV41738: Immunohistochemistry of LOR in Human Kidney tissue with LOR antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. SAB2108557). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type HepG2
| accession no. | NM_000427 |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 35 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | P23490  |
| Biochem/physiol Actions: | LOR is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in LOR may be the cause of both Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. |
| Biochem/physiol Actions: | Mutations in the gene LOR, leads to an autosomal dominant genodermatosis called loricrin keratoderma. The disease is characterized by palmoplantar keratoderma and ichthyosis. Variation in the gene also results in Vohwinkel syndrome with ichthyosis and progressive symmetrical erythrokeratodermia, an inherited cornification disorder. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The LOR gene codes for a a small basic protein, loricrin. It is predominantly localized to the cornified cell envelope. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human LOR |
| Other Notes: | Synthetic peptide located within the following region: GYSGGGCGGGSSGGGGGGGIGGCGG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |