Anti-MUC1
SIGMA/SAB2108549 - affinity isolated antibody
Synonym: Anti- EMA; Anti- PEM; Anti- PUM; Anti- mucin; Anti-CD227
Product Type: Product-on-demand
Immunohistochemistry Anti-MUC1 (ab1): Cat. No. SAB2108549: Immunohistochemistry of MUC1 in Human Kidney tissue with MUC1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. SAB2108549). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type Jurkat
Immunoblotting MUC1: Cat. No. SAB2108549: Western blot analysis of MUC1 in Human HepG2 cell lysates with MUC1 antibody at 1.0 μg/mL.
| accession no. | NM_001044390 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5-1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 22 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | horse, rat, rabbit, human, guinea pig, dog, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoblotting: suitable |
| immunohistochemistry: suitable | |
| UniProt accession no. | Q7Z552  |
| Q7Z552 |
| Biochem/physiol Actions: | MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human MUC1 |
| Other Notes: | Synthetic peptide located within the following region: GQLDIFPARDTYHPMSEYPTYHTHG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |