Anti-HYAL1 (ab2) antibody produced in rabbit
SIGMA/SAB2101113 - affinity isolated antibody
Synonym: Anti-HYAL-1; Anti-
Product Type: Chemical
Immunohistochemistry Anti-HYAL1 (ab2): Cat. No. SAB2101113: Immunohistochemistry of HYAL1 in Human Liver tissue with HYAL1 antibody at 5.0 μg/mL.
Immunoblotting Anti-HYAL1 (ab2): Cat. No.SAB2101113: HYAL1 in HepG2 cell lysate with HYAL1 antibody at 1.0 μg/mL.
Immunoblotting HYAL1: Cat. No. SAB2101113: Western blot analysis of HYAL1 in Human Fetal Brain cell lysates with HYAL1 antibody at 1.0 μg/mL.
Immunoblotting HYAL1: Cat. No. SAB2101113: Western blot analysis of HYAL1 in Human Fetal Lung cell lysates with HYAL1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 45 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, guinea pig, horse, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q12794  |
| Biochem/physiol Actions: | HYAL1 is a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. HYAL1 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for HYAL1.This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HYAL1 |
| Other Notes: | Synthetic peptide located within the following region: WNANTQWCLERHGVDVDVSVFDVVA |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |