Anti-EXOSC1 antibody produced in mouse
SIGMA/SAB1409395 - purified immunoglobulin, buffered aqueous solution
Synonym: CGI-108; CSL4; Csl4p; SKI4; Ski4p; hCsl4p; p13
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to EXOSC1 on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of EXOSC1 expression in transfected 293T cell line by EXOSC1 polyclonal antibody. Lanes Lane 1: EXOSC1 transfected lysate (21.45 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 21.5 kDa |
| NCBI accession no. | NM_016046   |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q9Y3B2 |
| Biochem/physiol Actions: | The exosome complex facilitates the splicing and degradation of mRNAs and non-coding RNAs. It is also essential for epigenetic gene regulation. It endogenously suppresses erythroid maturation. Within the complex, Exosc1 (exosome component 1) associates with Exosc6 to stabilize the complex. The binding of Exosc10 to Exosc1, Exosc6, and Exosc8 enhances the activity of the complex and positions Exosc1 for RNA binding. |
| General description: | This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. (provided by RefSeq) |
| Immunogen: | EXOSC1 (NP_057130.1, 1 a.a. ~ 195 a.a) full-length human protein. Sequence MAPPVRYCIPGERLCNLEEGSPGSG |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |