Anti-LBR antibody produced in mouse
SIGMA/SAB1400151 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-DHCR14B; Anti-LMN2R; Anti-MGC9041; Anti-PHA; Anti-PRO0650
MDL Number: MFCD01634008
Product Type: Chemical
Immunohistochemistry Immunoperoxidase of antibody to LBR on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 μg/mL]
Immunofluorescence Immunofluorescence of antibody to LBR on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of LBR expression in transfected 293T cell line by LBR polyclonal antibody. Lanes Lane 1: LBR transfected lysate (67.65 kDa). Lane 2: Non-transfected lysate.
Western Blotting LBR polyclonal antibody. Western Blot analysis of LBR expression in Jurkat.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| indirect immunofluorescence: suitable | |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q14739  |
| Biochem/physiol Actions: | Lamin B receptor (LBR) inhibits immature chromatin binding of proteins. It has a role in the construction of the nuclear envelope in vitro and in vivo. Mutation in the gene encoding LBR has been linked to Pelger-Huët anomaly (PHA). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Lamin B receptor (LBR) is a transmembrane protein which is expressed in the inner nuclear membrane. It possesses an amino-terminal domain, eight transmembrane domains and a carboxyl-terminal region. The gene encoding LBR is localized on human chromosome 1q42. |
| Immunogen: | LBR (NP_002287.2, 1 a.a. ~ 615 a.a) full-length human protein. Sequence MPSRKFADGEVVRGRWPGSSLYYEV |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |