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SMER28

SIGMA/S8197 - >99% (HPLC), solid

Synonym: 6-Bromo-N-2-propenyl-4-quinazolinamine

CAS Number: 307538-42-7
Empirical Formula (Hill Notation): C11H10BrN3
Molecular Weight: 264.12
MDL Number: MFCD02166825
Linear Formula: C11H10BrN3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S8197-5MG 5 mg
 $179.00
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45-S8197-25MG 25 mg
 $805.00
1/EA		 Add To Favorites

 

assay >99% (HPLC)
form solid
InChI 1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChI key BCPOLXUSCUFDGE-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1ccc2ncnc(NCC=C)c2c1
solubility DMSO: >20 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: SMER28 may be used in mTOR-mediated signaling studies.
Biochem/physiol Actions: SMER28 is a small molecule modulator of mammalian autophagy.
Biochem/physiol Actions: SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 37/38-41
Safety Statements 26-36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity >99% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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