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Stattic

SIGMA/S7947 - ≥98% (HPLC), powder

Synonym: 6-Nitrobenzo[b]thiophene-1,1-dioxide; Stat three inhibitory compound

CAS Number: 19983-44-9
Empirical Formula (Hill Notation): C8H5NO4S
Molecular Weight: 211.19
MDL Number: MFCD00173799
Linear Formula: C8H5NO4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S7947-25MG 25 mg
 $192.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI key ZRRGOUHITGRLBA-UHFFFAOYSA-N
Quality Level 100 
SMILES string [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
solubility DMSO: >20 mg/mL
Application: Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Application: Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5
Biochem/physiol Actions: Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Biochem/physiol Actions: Stattic is an irreversible STAT3 activation inhibitor.
Packaging: 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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